Hiroshi Manya Selected Research

Amyloid Plaque

1/2023	O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production.
11/2020	The Role of APP O-Glycosylation in Alzheimer's Disease.

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Hiroshi Manya Research Topics

Disease

25	Muscular Dystrophies (Muscular Dystrophy) 12/2023 - 03/2002
16	Walker-Warburg Syndrome 01/2016 - 03/2002
6	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 11/2008
2	Amyloid Plaque 01/2023 - 11/2020
2	Neoplasms (Cancer) 10/2021 - 08/2012
2	Eye Abnormalities (Eye Abnormality) 07/2006 - 10/2004
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2023
1	Cardiomyopathies (Cardiomyopathy) 01/2022
1	Dementia (Dementias) 11/2020
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 04/2016
1	Lissencephaly 03/2016
1	Melanoma (Melanoma, Malignant) 08/2012
1	Infections 11/2011
1	Chromosome Duplication 04/2011
1	Intellectual Disability (Idiocy) 04/2011
1	Neuroblastoma 01/2010
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2004
1	Group II Malformations of Cortical Development 01/2004
1	Hydrocephalus (Hydrocephaly) 03/2003
1	Protein Deficiency 09/2002
1	Arteriosclerosis 09/2002

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2004
14	Dystroglycans (Dystroglycan)IBA 01/2022 - 03/2002
13	Polysaccharides (Glycans)IBA 12/2023 - 11/2008
11	protein O-mannose beta-1,2-N-acetylglucosaminyltransferaseIBA 01/2020 - 03/2002
5	Amyloid (Amyloid Fibrils)IBA 01/2023 - 11/2008
4	RibitolIBA 01/2022 - 03/2016
3	Phosphates (Orthophosphate)IBA 01/2022 - 03/2016
3	Mannose (D-Mannose)IBA 01/2020 - 08/2012
2	EnzymesIBA 01/2022 - 01/2006
2	Laminin (Merosin)IBA 01/2018 - 04/2005
2	GlycosyltransferasesIBA 01/2016 - 12/2006
2	LigandsIBA 08/2012 - 03/2012
2	Amyloid beta-PeptidesIBA 01/2010 - 11/2008
2	protein O-mannosyltransferase (dolichyl-phosphate-mannose - protein mannosyltransferase)IBA 01/2008 - 01/2004
1	ProdrugsIBA 01/2022
1	Terpenes (Terpenoids)IBA 01/2022
1	cytidine diphosphate ribitolIBA 01/2022
1	TransferasesIBA 01/2020
1	SugarsIBA 02/2015
1	Peptide Hydrolases (Proteases)FDA Link 02/2015
1	Peptides (Polypeptides)IBA 02/2015
1	Epidermal Growth Factor (EGF)IBA 10/2013
1	O-GlcNAc transferaseIBA 10/2013
1	Alanine (L-Alanine)FDA Link 10/2013
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/2012
1	SulfotransferasesIBA 08/2012
1	Sulfates (Sulfates, Inorganic)IBA 08/2012
1	Galectin 1 (LGALS1)IBA 11/2011
1	DNA (Deoxyribonucleic Acid)IBA 04/2011
1	Messenger RNA (mRNA)IBA 01/2010
1	DystrophinIBA 01/2006
1	Glycoproteins (Glycoprotein)IBA 01/2006
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2004
1	MannosyltransferasesIBA 01/2004
1	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase)IBA 06/2003
1	SpectrinIBA 09/2002
1	mu-calpainIBA 09/2002

Therapy/Procedure

1	Therapeutics 01/2022